Hyodeoxycholic acid: a new approach to gallstone prevention.

Abstract

Hyodeoxycholic acid and its isomer, 6 beta-hyodeoxycholic acid, when added to a lithogenic diet prevented the formation of cholesterol gallstones and crystals in prairie dogs. This beneficial effect occurred in the presence of bile supersaturated with cholesterol. Hyodeoxycholic acid abolished the feedback inhibition of hepatic hydroxymethylglutaryl coenzyme A reductase activity, the rate-limiting enzyme of cholesterol synthesis, and prevented elevations in serum and liver cholesterol observed in animals fed a 0.4 percent cholesterol diet. The gallbladder bile of the animals fed hyodeoxycholic acid and 6 beta-hyodeoxycholic acid contained abundant liquid crystals. This suggests that these bile acids prevented the transition of cholesterol from its liquid crystalline phase to solid crystals and stones.

• Authors: C K McSherry, E H Mosbach, B I Cohen, M Une, R J Stenger, A K Singhal
• Journal: American journal of surgery (Am J Surg) Vol. 149 Issue 1 Pg. 126-32 (Jan 1985) ISSN: 0002-9610 [Print] United States
• PMID: 3970744 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Cholesterol, Dietary
• Deoxycholic Acid
• glycohyodeoxycholic acid
• Glycodeoxycholic Acid
• hyodeoxycholic acid
• Cholesterol
• Hydroxymethylglutaryl CoA Reductases

Topics

• Animals
• Bile (metabolism)
• Cholelithiasis (etiology, prevention & control)
• Cholesterol (metabolism)
• Cholesterol, Dietary
• Crystallization
• Deoxycholic Acid (administration & dosage, pharmacology)
• Diet
• Disease Models, Animal
• Female
• Glycodeoxycholic Acid (pharmacology)
• Hydroxymethylglutaryl CoA Reductases (metabolism)
• Liver (metabolism)
• Male
• Microsomes, Liver (enzymology)
• Sciuridae