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Carbon tetrachloride-induced inhibition of hepatocyte lipoprotein secretion: functional impairment of Golgi apparatus in the early phases of such injury.

Abstract
Functional change of liver Golgi apparatus during carbon tetrachloride (CCl4) poisoning was demonstrated both in rat isolated hepatocytes and in the whole animal. The "in vitro" experimental model provided evidence of Golgi derangement early after giving the haloalkane. The "in vivo" analyses also showed that such an alteration involves both formative and secretory sides of the subcellular structure.
AuthorsG Poli, E Chiarpotto, E Albano, D Cottalasso, G Nanni, U M Marinari, A M Bassi, M U Dianzani
JournalLife sciences (Life Sci) Vol. 36 Issue 6 Pg. 533-9 (Feb 11 1985) ISSN: 0024-3205 [Print] Netherlands
PMID3968976 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Lipoproteins
  • Palmitic Acids
  • Triglycerides
  • Palmitic Acid
Topics
  • Animals
  • Carbon Tetrachloride Poisoning (metabolism)
  • Golgi Apparatus (metabolism)
  • Lipoproteins (metabolism)
  • Liver (drug effects, ultrastructure)
  • Male
  • Palmitic Acid
  • Palmitic Acids (metabolism)
  • Rats
  • Rats, Inbred Strains
  • Triglycerides (metabolism)

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