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Immunologic effects of nickel. II. Suppression of natural killer cell activity.

Abstract
A single intramuscular injection of nickel chloride (18.3 mg/kg) caused a significant reduction in murine splenic natural killer (NK) cell activity. This reduction in NK activity was not associated with a significant reduction in spleen cellularity nor in the production of suppressor cells. In a 4-hr 51Cr-release assay, NK cell activity was suppressed in both CBA/J and C57BL/6J mice. Administration of the nickel dose (i.e., 18.3 mg/kg total) over a 2-week period also caused a significant reduction in NK cell activity. In an in vivo NK assay, the clearance of [125I]iododeoxyuridine-labeled YAC-1 tumor cells from the lungs of nickel-treated mice was significantly reduced compared with saline injected controls. Another in vivo correlate of nickel-induced NK suppression was observed in mice injected with the B16-F10 melanoma. Mice given a single intramuscular injection of NiCl2 (18.3 mg/kg) developed significantly greater numbers of lung tumors than saline controls. The results indicate that NiCl2 is a potent suppressor of NK cell activity.
AuthorsR J Smialowicz, R R Rogers, M M Riddle, R J Garner, D G Rowe, R W Luebke
JournalEnvironmental research (Environ Res) Vol. 36 Issue 1 Pg. 56-66 (Feb 1985) ISSN: 0013-9351 [Print] Netherlands
PMID3967644 (Publication Type: Journal Article)
Chemical References
  • Chromium Radioisotopes
  • nickel chloride
  • Nickel
Topics
  • Animals
  • Chromium Radioisotopes
  • Female
  • Immunosuppression Therapy
  • Injections, Intramuscular
  • Killer Cells, Natural (drug effects, immunology, metabolism)
  • Kinetics
  • Lung Neoplasms (immunology)
  • Lymphoma (immunology)
  • Male
  • Melanoma (immunology)
  • Mice
  • Mice, Inbred C57BL
  • Mice, Inbred CBA
  • Neoplasms, Experimental (immunology)
  • Nickel (immunology, toxicity)
  • Spleen (drug effects, immunology)

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