| Abstract | A single intramuscular injection of nickel chloride (18.3 mg/kg) caused a significant reduction in murine splenic natural killer (NK) cell activity. This reduction in NK activity was not associated with a significant reduction in spleen cellularity nor in the production of suppressor cells. In a 4-hr 51Cr-release assay, NK cell activity was suppressed in both CBA/J and C57BL/6J mice. Administration of the nickel dose (i.e., 18.3 mg/kg total) over a 2-week period also caused a significant reduction in NK cell activity. In an in vivo NK assay, the clearance of [125I]iododeoxyuridine-labeled YAC-1 tumor cells from the lungs of nickel-treated mice was significantly reduced compared with saline injected controls. Another in vivo correlate of nickel-induced NK suppression was observed in mice injected with the B16-F10 melanoma. Mice given a single intramuscular injection of NiCl2 (18.3 mg/kg) developed significantly greater numbers of lung tumors than saline controls. The results indicate that NiCl2 is a potent suppressor of NK cell activity. |
| Authors | R J Smialowicz, R R Rogers, M M Riddle, R J Garner, D G Rowe, R W Luebke |
| Journal | Environmental research
(Environ Res)
Vol. 36
Issue 1
Pg. 56-66
(Feb 1985)
ISSN: 0013-9351 UNITED STATES |
| PMID | 3967644
(Publication Type: Journal Article)
|
| Chemical References |
- Chromium Radioisotopes
- Nickel
- nickel chloride
|
| Topics |
- Animals
- Chromium Radioisotopes
(diagnostic use)
- Female
- Immunosuppression
- Injections, Intramuscular
- Killer Cells, Natural
(drug effects, immunology, metabolism)
- Kinetics
- Lung Neoplasms
(immunology)
- Lymphoma
(immunology)
- Male
- Melanoma
(immunology)
- Mice
- Mice, Inbred C57BL
- Mice, Inbred CBA
- Neoplasms, Experimental
(immunology)
- Nickel
(immunology, toxicity)
- Spleen
(drug effects, immunology)
|
