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Estrogen and progesterone receptors in primary cutaneous melanoma.

Abstract
Using a variety of techniques, estrogen and progesterone receptors have previously been identified in variable percentages of malignant melanomas. We examined 10 primary superficial spreading melanomas (SSM) with a fluorescent hormone-binding technique for estrogen and progesterone cytoplasmic receptors. Of these 6 SSM were markedly positive for estrogen and progesterone binding. Patients with dysplastic nevus syndrome (DNS) or a family history of DNS were markedly positive for estrogen and progesterone binding. A single patient with lentigo maligna and another patient with lentigo maligna melanoma were negative for estrogen and progesterone binding. None of the 21 control intradermal nevi examined for estrogen and progesterone binding exhibited marked positivity.
AuthorsD L Ellis, R G Wheeland, H Solomon
JournalThe Journal of dermatologic surgery and oncology (J Dermatol Surg Oncol) Vol. 11 Issue 1 Pg. 54-9 (Jan 1985) ISSN: 0148-0812 [Print] United States
PMID3965520 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Receptors, Estrogen
  • Receptors, Progesterone
Topics
  • Adult
  • Aged
  • Female
  • Humans
  • Male
  • Melanoma (analysis)
  • Middle Aged
  • Nevus, Pigmented (analysis)
  • Receptors, Estrogen
  • Receptors, Progesterone
  • Skin Neoplasms (analysis)

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