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[Immunomodulation by antitumor antibiotics].

Abstract
Antibiotics exhibiting immunomodulatory activities were found among antitumor antibiotics. These antibiotics had antileukemic activity. Neothramycin and mazethramycin, which are classified as anthramycin-group antibiotics, activated macrophages so that they became antitumor effector cells. Aclacinomycin and oxanosine inhibited generation of suppressor cells in tumor-bearing mice and oxanosine enhanced antitumor effector cells. Therapy using spergualin produced specific antitumor immunity in cured mice. The immunomodulatory activities of auromomycin and bactobolin were also reported.
AuthorsM Ishizuka
JournalGan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 13 Issue 3 Pt 2 Pg. 697-700 (Mar 1986) ISSN: 0385-0684 [Print] Japan
PMID3963840 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Anti-Bacterial Agents
  • Antibiotics, Antineoplastic
  • Benzodiazepinones
  • Guanidines
  • Naphthacenes
  • Peptides
  • Ribonucleosides
  • aclacinomycins
  • auromomycin
  • Anthramycin
  • neothramycins
  • mazethramycin
  • spergualin
  • Aclarubicin
  • oxanosine
Topics
  • Aclarubicin (analogs & derivatives)
  • Animals
  • Anthramycin (analogs & derivatives, pharmacology)
  • Anti-Bacterial Agents
  • Antibiotics, Antineoplastic (pharmacology)
  • Benzodiazepinones (pharmacology)
  • Guanidines (pharmacology)
  • Immune Tolerance (drug effects)
  • Leukemia L1210 (drug therapy, immunology)
  • Mice
  • Naphthacenes (pharmacology)
  • Peptides (pharmacology)
  • Ribonucleosides (pharmacology)

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