[Topical treatment of glucocorticoid-sensitive dermatoses with diflorasone diacetate].

Treatment with diflorasone diacetate ointment and cream (0.05%) was strikingly successful in a multicenter clinical trial involving 4,651 patients in total suffering from various corticosteroid-sensitive dermatoses. According to the clinical evaluation, 93% of the patients were cured or much improved. Approximately 7% of the patients questioned rated the local tolerance of the two forms of administration as good to very good. Only 4% of the patients rated the tolerance of the ointment or cream as moderate or bad. None of the patients showed any systemic side-effects. The molecular structure of diflorasone-17,21-diacetate and the specific pharmaceutical properties of the ointment and cream evidently guarantee a good bioavailability of the glucocorticosteroid in the skin. Clinical and experimental results confirm that diflorasone diacetate belongs to the group of highly active corticosteroids.
AuthorsT A Rozman
JournalZeitschrift für Hautkrankheiten (Z Hautkr) Vol. 61 Issue 5 Pg. 294, 297-304 (Mar 1 1986) ISSN: 0301-0481 [Print] GERMANY, WEST
Vernacular TitleAusserliche Behandlung von Glukokortikoid-empfindlichen Dermatosen mit Diflorason-diacetat.
PMID3962411 (Publication Type: Comparative Study, English Abstract, Journal Article)
Chemical References
  • Betamethasone
  • diflorasone
  • Administration, Topical
  • Adolescent
  • Adult
  • Aged
  • Betamethasone (adverse effects, analogs & derivatives, therapeutic use)
  • Child
  • Dermatitis (drug therapy)
  • Dermatitis, Atopic (drug therapy)
  • Dermatitis, Contact (drug therapy)
  • Eczema (drug therapy)
  • Female
  • Humans
  • Male
  • Middle Aged
  • Psoriasis (drug therapy)
  • Skin (drug effects)

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