Facilitation of lordosis behavior in ovariectomized estrogen-primed rats by medial preoptic implantation of 5 beta, 3 beta, pregnanolone: a ring A reduced progesterone metabolite.

Abstract	The effect on lordosis behavior of progesterone (P) and some of its ring A reduced metabolites (5 beta pregnane 3 alpha ol 20 one, 5 beta pregnane 3 beta ol 20 one and 5 alpha pregnanes 3 beta ol 20 one) was studied in estrogen primed overiectomized rats by unilaterally implanting them in two brain areas related to the control of lordosis behavior: the ventromedial hypothalamic nucleus (VMH) and the medial preoptic area (mPOA). Of the four pregnanes studied only 5 beta 3 beta pregnanolone consistently induced lordosis behavior when implanted into the mPOA. The present results show that some 5 beta reduced P metabolites can facilitate with a short latency the display of lordosis behavior, probably by depressing the activity of telencephalic neurons inhibitory to sexual behavior.
Authors	G Rodriguez-Manzo, M L Cruz, C Beyer
Journal	Physiology & behavior (Physiol Behav) Vol. 36 Issue 2 Pg. 277-81 ( 1986) ISSN: 0031-9384 [Print] United States
PMID	3961001 (Publication Type: Comparative Study, Journal Article)
Chemical References	Pregnanes Progesterone Estradiol Pregnanolone
Topics	Animals Estradiol (pharmacology) Female Hypothalamus, Middle (drug effects) Ovariectomy Posture Pregnanes (pharmacology) Pregnanolone (pharmacology) Preoptic Area (drug effects) Progesterone (pharmacology) Rats Rats, Inbred Strains Sexual Behavior, Animal (drug effects) Stereoisomerism

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