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Creatinol O-phosphate therapy in patients with inadequate coronary circulation. Double-blind clinical trial.

Abstract
N-Methyl-N-(beta-hydroxyethyl) guanidine O-phosphate (creatinol O-phosphate, COP) was checked on patients suffering from inadequate coronary circulation (12 patients had a recent myocardial infarction and 13 were suffering from angina pectoris) versus a reference substance (solvent of COP) in a double blind study. COP improved rhythm disturbances, chest pains and symptoms of contractility failure to a statistically significant degree.
AuthorsM Barlattani, G Guglielmi, A Mammarella
JournalArzneimittel-Forschung (Arzneimittelforschung) Vol. 29 Issue 9a Pg. 1483-5 ( 1979) ISSN: 0004-4172 [Print] Germany
PMID395958 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)
Chemical References
  • creatinol phosphate
  • Creatine
Topics
  • Adult
  • Aged
  • Blood Pressure (drug effects)
  • Clinical Trials as Topic
  • Coronary Disease (drug therapy, physiopathology)
  • Creatine (adverse effects, analogs & derivatives, therapeutic use)
  • Double-Blind Method
  • Female
  • Heart Rate (drug effects)
  • Humans
  • Male
  • Middle Aged

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