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Absolute configuration of (-)-5-benzoyl-1,2-dihydro-3H-pyrrolo[1,2-alpha]pyrrole-1-carboxylic acid, the active enantiomer of ketorolac.

Abstract
The (-)-S isomer of 5-benzoyl-1,2-dihydro-3H-pyrrolo[1,2-alpha]pyrrole-1-carboxylic acid is about 60 times more potent than the (+)-R isomer in the carrageenan edema test and ca. 230 times more active than the (+)-R isomer in the mouse phenylquinone writhing assay.
AuthorsA Guzmán, F Yuste, R A Toscano, J M Young, A R Van Horn, J M Muchowski
JournalJournal of medicinal chemistry (J Med Chem) Vol. 29 Issue 4 Pg. 589-91 (Apr 1986) ISSN: 0022-2623 [Print] United States
PMID3959034 (Publication Type: Journal Article)
Chemical References
  • Analgesics
  • Anti-Inflammatory Agents
  • Pyrroles
  • Tolmetin
  • Ketorolac
Topics
  • Analgesics (pharmacology)
  • Animals
  • Anti-Inflammatory Agents (pharmacology)
  • Ketorolac
  • Mice
  • Molecular Conformation
  • Pyrroles
  • Rats
  • Stereoisomerism
  • Tolmetin (analogs & derivatives)

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