Abstract |
The (-)-S isomer of 5-benzoyl-1,2-dihydro-3H-pyrrolo[1,2-alpha] pyrrole-1- carboxylic acid is about 60 times more potent than the (+)-R isomer in the carrageenan edema test and ca. 230 times more active than the (+)-R isomer in the mouse phenylquinone writhing assay.
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Authors | A Guzmán, F Yuste, R A Toscano, J M Young, A R Van Horn, J M Muchowski |
Journal | Journal of medicinal chemistry
(J Med Chem)
Vol. 29
Issue 4
Pg. 589-91
(Apr 1986)
ISSN: 0022-2623 [Print] United States |
PMID | 3959034
(Publication Type: Journal Article)
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Chemical References |
- Analgesics
- Anti-Inflammatory Agents
- Pyrroles
- Tolmetin
- Ketorolac
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Topics |
- Analgesics
(pharmacology)
- Animals
- Anti-Inflammatory Agents
(pharmacology)
- Ketorolac
- Mice
- Molecular Conformation
- Pyrroles
- Rats
- Stereoisomerism
- Tolmetin
(analogs & derivatives)
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