Radiotherapeutic prophylaxis of estrogen-induced gynecomastia: a study of late sequela.

Abstract

Radiation therapy is an effective means of preventing the development of hormone-induced gynecomastia in men with cancer of the prostate. The efficacy and morbidity of this type of radiation was studied in a retrospective analysis of 87 patients referred for treatment from 1972 to 1982. Patients receiving DES as treatment for prostate carcinoma were treated with irradiation to the breast tissue. Patients were treated with 4 MV, 60Co superficial X rays. Doses range from 1200 to 1500 cGy in 3 fractions. The majority of patients had satisfactory results in terms of prevention of gynecomastia and mammalgia. There were few acute reactions noted and no evidence of long term sequela.

• Authors: D Fass, A Steinfeld, J Brown, A Tessler
• Journal: International journal of radiation oncology, biology, physics (Int J Radiat Oncol Biol Phys) Vol. 12 Issue 3 Pg. 407-8 (Mar 1986) ISSN: 0360-3016 [Print] United States
• PMID: 3957739 (Publication Type: Journal Article)

Chemical References

• Diethylstilbestrol

Topics

• Aged
• Breast (radiation effects)
• Diethylstilbestrol (therapeutic use)
• Gynecomastia (chemically induced, prevention & control, radiotherapy)
• Humans
• Male
• Prostatic Neoplasms (drug therapy)