Developmental pharmacology and therapeutics of piperacillin in gram-negative infections.

Twenty children ranging in age from 1 week to 19 years with documented or suspected bacterial infections arising outside the central nervous system were studied. Pharmacokinetic analysis was possible in 15 children; 8 after the first dose, 6 during steady-state conditions, and 4 on both occasions. Data were obtained utilizing noncompartmental pharmacokinetic methods. Peak piperacillin serum concentrations ranged from 51 to 232 mg/l and correlated directly (r = 0.75) with the dose administered. In children with normal renal function, there was an age-dependent decrease in elimination half-life and apparent steady-state volume of distribution, whereas plasma clearance increased logarithmically. All but 1 child responded favorably to piperacillin therapy, and 1 child with a urinary tract infection relapsed 10 days after discontinuation of the therapy. Although improved clinically, piperacillin monotherapy failed to eradicate pathogens in 2 children. No adverse clinical or biochemical effects were observed in any child.
AuthorsM D Reed, C M Myers, T S Yamashita, J L Blumer
JournalDevelopmental pharmacology and therapeutics (Dev Pharmacol Ther) Vol. 9 Issue 2 Pg. 102-14 ( 1986) ISSN: 0379-8305 [Print] SWITZERLAND
PMID3956344 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Piperacillin
  • Adolescent
  • Adult
  • Aging
  • Bacterial Infections (drug therapy, microbiology)
  • Child
  • Child, Preschool
  • Female
  • Gram-Negative Bacteria (drug effects)
  • Humans
  • Infant
  • Kinetics
  • Male
  • Models, Biological
  • Piperacillin (pharmacology, therapeutic use, urine)
  • Urinary Tract Infections (drug therapy, microbiology)

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