Porphyria cutanea tarda. Diagnosis, management, and differentiation from other hepatic porphyrias.

Abstract

Porphyria cutanea tarda is a photocutaneous syndrome characterized clinically by cutaneous fragility, bullae, hypertrichosis, pigmentary changes, and sclerodermoid plaques and characterized biochemically by hepatic overproduction and storage of excessive amounts of porphyrins. Porphyria cutanea tarda, the most common disorder of porphyrin metabolism, must be differentiated from variegate porphyria, hereditary coproporphyria, bullous dermatosis of hemodialysis, and drug-related pseudoporphyria.

• Authors: M E Grossman, M B Poh-Fitzpatrick
• Journal: Dermatologic clinics (Dermatol Clin) Vol. 4 Issue 2 Pg. 297-309 (Apr 1986) ISSN: 0733-8635 [Print] United States
• PMID: 3955900 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Porphyrins

Topics

• Biopsy
• Bloodletting
• Diagnosis, Differential
• Female
• Humans
• Liver (metabolism, pathology)
• Male
• Photosensitivity Disorders (etiology, pathology)
• Plasmapheresis
• Porphyrias (complications, diagnosis, pathology, therapy)
• Porphyrins (biosynthesis)
• Pregnancy
• Skin (pathology)
• Skin Diseases (complications, diagnosis, pathology, therapy)