Abstract |
The aims were to see whether p-hydroxymercuribenzoate (PMB) administration affects the serum insulin concentration in mice in vivo, whether the transitory hyperglycemia induced in fed mice by treatment with PMB is affected by L-leucine, tolbutamide, D- mannoheptulose or insulin, and whether PMB affects the B-cell toxicity of alloxan. A significant decrease in the serum insulin concentration was found 1 and 2 h following PMB injection in fed and starved mice. PMB-induced hyperglycemia was abolished by pre-treatment with L-leucine and tolbutamide, but not by pre-treatment with D- mannoheptulose, or by post-treatment with insulin. Pre-treatment of fed mice with PMB caused potentiation of the initial hyperglycemia following alloxan, but inhibited the second hyperglycemic phase. These findings indicate that PMB treatment of mice has a transient inhibitory influence upon insulin secretion, and protects against the development of alloxan diabetes.
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Authors | L Boquist |
Journal | Journal of endocrinological investigation
(J Endocrinol Invest)
1979 Oct-Dec
Vol. 2
Issue 4
Pg. 413-7
ISSN: 0391-4097 [Print] Italy |
PMID | 395187
(Publication Type: Journal Article)
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Chemical References |
- Blood Glucose
- Hydroxymercuribenzoates
- Insulin
- Mannoheptulose
- Alloxan
- Tolbutamide
- Leucine
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Topics |
- Alloxan
(pharmacology)
- Animals
- Blood Glucose
(analysis)
- Hydroxymercuribenzoates
(pharmacology)
- Hyperglycemia
(chemically induced)
- Insulin
(blood, pharmacology)
- Islets of Langerhans
(drug effects)
- Leucine
(pharmacology)
- Male
- Mannoheptulose
(pharmacology)
- Mice
- Tolbutamide
(pharmacology)
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