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Fixed-dose combination diuretics in congestive heart failure: an evaluation.

Abstract
Thirty-two patients with congestive heart failure were studied for their clinical and biochemical responses to the administration of two combination diuretic products (hydrochlorothiazide/spironolactone and hydrochlorothiazide/triamterene) and the single entity diuretic furosemide. Data from these studies revealed the following: 1. Comparison of the patients on furosemide with those receiving the combination products showed no difference in serum potassium or 24-hour potassium excretion. 2. Significant changes in blood urea nitrogen, plasma renin activity, and urinary aldosterone excretion were noted with both fixed-combination medications but not with furosemide. 3. The combination diuretics offered no clinical benefits over the single agent furosemide. 4. Therapy is best served by the use of a single effective diuretic agent for the treatment of most patients with congestive heart failure.
AuthorsB Levy
JournalJournal of clinical pharmacology (J Clin Pharmacol) 1979 Nov-Dec Vol. 19 Issue 11-12 Pg. 743-6 ISSN: 0091-2700 [Print] England
PMID395175 (Publication Type: Journal Article)
Chemical References
  • Diuretics
  • Drug Combinations
  • Hydrochlorothiazide
  • Spironolactone
  • Renin
Topics
  • Blood Urea Nitrogen
  • Diuretics (administration & dosage, therapeutic use)
  • Drug Combinations
  • Heart Failure (drug therapy)
  • Humans
  • Hydrochlorothiazide (therapeutic use)
  • Renin (blood)
  • Spironolactone (therapeutic use)

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