Abstract |
Anesthetized and nonanesthetized animals (white rats and cats) were used to study the effect of dibasol and its new imidazo analogs (designated AKS-67 and AKS-87) on animal tolerance to gravitational effects and cerebral ischemia ( ligation of both carotid arteries) as well as on systemic arterial pressure and tone of cerebral and peripheral vessels (resistographically) in the postischemic period. The drugs were administered 30-90 min before exposure. It was found that in nonanesthetized rats dibasol and AKS-87 increased tolerance to cranio-caudal acceleration and decreased it to caudo-cranial acceleration, whereas AKS-67 produced a distinct protective effect regardless of the vector. In anesthetized rats (bilateral carotid ligation) AKS-67 and AKS-87 increased acceleration tolerance and dibasol produced no protective effect. Dibasol enhanced postischemic hypotension while AKS-67 and AKS-87 delayed or completely arrested it. For aerospace medicine the drug AKS-67 is of particular importance because it increases significantly animal tolerance to acceleration and stabilizes arterial pressure in the postischemic period.
|
Authors | V K Vereshchagin, M D Gaevyĭ |
Journal | Kosmicheskaia biologiia i aviakosmicheskaia meditsina
(Kosm Biol Aviakosm Med)
1986 Jan-Feb
Vol. 20
Issue 1
Pg. 67-70
ISSN: 0321-5040 [Print] Russia (Federation) |
Vernacular Title | Vliianie dibazola i nekotorykh ego imidazoanalogov na ustoĭchivost' zhivotnykh k gravitatsionnym peregruzkam i dinamiku razvitiia postishemicheskikh tserebrovaskuliarnykh fenomenov. |
PMID | 3951181
(Publication Type: Comparative Study, English Abstract, Journal Article)
|
Chemical References |
- AKS 67
- AKS 87
- Benzimidazoles
- bendazole
|
Topics |
- Animals
- Benzimidazoles
(therapeutic use)
- Blood Pressure
- Brain
(blood supply)
- Brain Ischemia
(prevention & control)
- Cats
- Female
- Gravitation
- Hindlimb
(blood supply)
- Hypoxia, Brain
(prevention & control)
- Male
- Rats
|