Gonadal tumor and H-Y antigen in 46,XY pure gonadal dysgenesis.

Abstract

Six cases of Swyer's syndrome (46,XY pure gonadal dysgenesis) are reported. Three patients, without gonadal tumor, had female H-Y antigen. Three patients, after gonadal tumor ablation, had intermediate H-Y antigen levels. Repeated blood samples were obtained from two siblings. H-Y antigen level in the first sibling, who presented with a gonadoblastoma and underwent a gonadectomy before the H-Y assays, was intermediate, and did not show any significant variation for 21 months. H-Y antigen level in the second sibling showed an increase in the male range, presumably due to the presence of gonadoblastomas. After resection of the tumors, H-Y antigen level became intermediate. These findings suggest a relation between the tumorization potentiality of the gonadal remnants and the H-Y antigen levels in 46,XY pure gonadal dysgenesis.

• Authors: V Amice, J Amice, J P Bercovici, D Riviere, M J Corolleur
• Journal: Cancer (Cancer) Vol. 57 Issue 7 Pg. 1313-7 (Apr 01 1986) ISSN: 0008-543X [Print] United States
• PMID: 3948114 (Publication Type: Case Reports, Comparative Study, Journal Article)

Chemical References

• H-Y Antigen

Topics

• Adolescent
• Adult
• Child
• Child, Preschool
• Dysgerminoma (complications, immunology)
• Female
• Genital Neoplasms, Female (complications, immunology)
• Gonadal Dysgenesis (immunology)
• Gonadal Dysgenesis, 46,XY (complications, immunology)
• H-Y Antigen (analysis)
• Humans
• Karyotyping
• Leukocytes (immunology)
• Male
• Virilism (complications)