Different effects of the polysaccharide levan on the oncogenicity of cells of two variants of Lewis lung carcinoma.

Abstract

A marked difference in sensitivity to the direct effect of the polysaccharide levan on tumour cells was observed between two variants of malignancy of Lewis lung carcinoma: cells of the more malignant variant (3LL-M) were much more sensitive to the drug than those of the less malignant tumour (3LL). A gradual decrease in tumorigenicity following preincubation with increasing levan concentrations was observed with both variants, but statistically significant inhibition was observed at lower levan concentrations with 3LL-M than with 3LL.

• Authors: Y Stark, J Leibovici
• Journal: British journal of experimental pathology (Br J Exp Pathol) Vol. 67 Issue 1 Pg. 141-7 (Feb 1986) ISSN: 0007-1021 [Print] England
• PMID: 3947532 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Fructans
• Polysaccharides

Topics

• Animals
• Cell Survival (drug effects)
• Cell Transformation, Neoplastic (drug effects)
• Fructans (pharmacology)
• Lung Neoplasms (physiopathology, prevention & control, secondary)
• Male
• Mice
• Mice, Inbred C57BL
• Neoplasm Metastasis
• Neoplasm Transplantation
• Polysaccharides (pharmacology)