Protection of guinea pigs against cutaneous leishmaniasis by combined infection and chemotherapy.

Abstract

A paromomycin and methylbenzethonium chloride ointment cured Leishmania enriettii infections in guinea pigs. Amastigotes were totally eliminated from the treated lesion after 10 days of treatment. A delayed effect also occurred on untreated lesions in the same animals. Lesions treated at various times after infection permitted protective immunity to develop, and 90% of treated animals were refractory to reinfection.

• Authors: J El-On, A Witztum, L F Schnur
• Journal: Infection and immunity (Infect Immun) Vol. 51 Issue 2 Pg. 704-6 (Feb 1986) ISSN: 0019-9567 [Print] United States
• PMID: 3943909 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies
• Drug Combinations
• Ointments
• Quaternary Ammonium Compounds
• Benzethonium
• Paromomycin
• methylbenzethonium chloride

Topics

• Animals
• Antibodies (analysis)
• Benzethonium (administration & dosage, analogs & derivatives)
• Drug Combinations
• Guinea Pigs
• Leishmaniasis (drug therapy, immunology)
• Ointments
• Paromomycin (administration & dosage)
• Quaternary Ammonium Compounds (administration & dosage)
• Vaccination