[Effect of chlorgyline on gamma-aminobutyric acid levels in hyperoxia].

Abstract

Chlorgyline, an inhibitor of type A monoamine oxidase, administered to rats prevented oxygen-induced decrease in gamma-aminobutyric acid brain content in hyperoxia. At the same time chlorgyline had an overall protective effect, increasing two-fold the period prior to the development of oxygen convulsions. The data suggest an important role of the modification of monoamine oxidase catalytic properties in the development of oxygen-induced intoxication and, particularly, in the decrease of gamma-aminobutyric acid content in hyperoxia.

• Authors: I A Goroshinskaia, K B Sherstnev
• Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 101 Issue 1 Pg. 45-6 (Jan 1986) ISSN: 0365-9615 [Print] Russia (Federation)
• Vernacular Title: Vliianie khlorgilina na uroven' gamma-aminomaslianoĭ kisloty pri giperoksii.
• PMID: 3942814 (Publication Type: English Abstract, Journal Article)

Chemical References

• Propylamines
• gamma-Aminobutyric Acid
• Clorgyline
• Oxygen

Topics

• Animals
• Brain (metabolism)
• Clorgyline (pharmacology)
• Female
• Male
• Oxygen (toxicity)
• Propylamines (pharmacology)
• Rats
• Seizures (chemically induced, metabolism, prevention & control)
• gamma-Aminobutyric Acid (metabolism)