Effects of dicarboxylic acids on normal and malignant melanocytes in culture.

We have shown that dicarboxylic acids (C9 and C12), known competitive inhibitors of tyrosinase, are selectively cytotoxic to malignant melanogenic melanocytes but not to normal pigmented cells or to amelanotic or non-melanogenic melanoma cells. The main target of this toxicity appears to be the mitochondria, which become markedly swollen and vacuolated. The mechanism of their action has been thought to be due to interference with oxidoreductases in the mitochondria. However, our results suggest that this cytotoxicity most probably does not result simply from inhibition of mitochondrial enzymes, but is closely related to the melanin biosynthesis pathway.
AuthorsF Hu, K Mah, D J Teramura
JournalThe British journal of dermatology (Br J Dermatol) Vol. 114 Issue 1 Pg. 17-26 (Jan 1986) ISSN: 0007-0963 [Print] ENGLAND
PMID3942687 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Dicarboxylic Acids
  • dodecanedioic acid
  • azelaic acid
  • Animals
  • Cell Line
  • Dicarboxylic Acids (pharmacology)
  • Macaca fascicularis
  • Macaca mulatta
  • Melanocytes (drug effects, ultrastructure)
  • Melanoma (pathology, ultrastructure)
  • Mice
  • Mice, Inbred C57BL
  • Microscopy, Electron

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