Peroxisome proliferators show tumor-promoting but no direct transforming activity in vitro.

Abstract

The chemically unrelated hypolipidemic drugs, tiadenol, niadenate, and clofibrate have been tested for carcinogenic and tumor-promoting potential in the C3H/10TI/2 C18 cell test system. None of these chemicals were carcinogenic, while both niadenate and clofibrate were active tumor promoters at micromolar concentrations. All 3 drugs induced the differentiation of C3H/10T1/2 C18 cells to adipocytes. This latter finding confirms previously observed effects of the tumor promoter TPA.

• Authors: J R Lillehaug, N Aarsaether, R K Berge, R Male
• Journal: International journal of cancer (Int J Cancer) Vol. 37 Issue 1 Pg. 97-100 (Jan 15 1986) ISSN: 0020-7136 [Print] United States
• PMID: 3941024 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Carcinogens
• Fatty Alcohols
• Hypolipidemic Agents
• Nicotinic Acids
• tiadenol
• niadenate
• Clofibrate
• Tetradecanoylphorbol Acetate

Topics

• Adipose Tissue (drug effects)
• Animals
• Carcinogens
• Cell Division (drug effects)
• Cell Transformation, Neoplastic (drug effects)
• Clofibrate (toxicity)
• Dose-Response Relationship, Drug
• Fatty Alcohols (toxicity)
• Hypolipidemic Agents (toxicity)
• Mice
• Microbodies (drug effects)
• Nicotinic Acids (toxicity)
• Tetradecanoylphorbol Acetate