Lymphatic distribution of an anti-tumor agent in postoperative adjuvant chemotherapy in gastric cancer: fat-emulsified preparation of 1-(2-tetrahydrofuryl)-5-fluorouracil in lymph.

Abstract

In 8 postoperative patients with gastric cancer the effectiveness of fat emulsification of tegafur as a means of improving the drug distribution in the lymphatic tissue was studied. A water-in-oil type of emulsion of tegafur (FT-w/o) and an oil-in-water type of emulsion of tegafur (FT-o/w) were orally administered. A fistula in the thoracic duct, prepared in advance, was used to collect lymph. The concentrations of tegafur and 5-FU were compared in simultaneously obtained specimens of lymph and peripheral blood. In the case of FT-w/o, the tegafur concentration at 30-60 min after administration was significantly higher in both the lymph and plasma than that found using FT-o/w. In the case of FT-w/o, the 5-FU concentration at 30-120 min after the administration was significantly higher than that found with FT-o/w in both the lymph and the plasma. Thus, FT-w/o shows excellent distribution in both lymph and blood, and is considered useful as an adjuvant chemotherapeutic agent in the postoperative treatment of gastric cancer patients.

• Authors: H Hanaue, T Kurosawa, S Miyakawa, F Horie, A Nemoto, S Nishimura, H Yamoto, H Yasuda, T Asagoe, S Miura
• Journal: Japanese journal of cancer research : Gann (Jpn J Cancer Res) Vol. 76 Issue 12 Pg. 1230-5 (Dec 1985) ISSN: 0910-5050 [Print] Japan
• PMID: 3937835 (Publication Type: Journal Article)

Chemical References

• Emulsions
• Tegafur

Topics

• Administration, Oral
• Adult
• Combined Modality Therapy
• Emulsions
• Humans
• Lymph (metabolism)
• Lymphoid Tissue (metabolism)
• Male
• Middle Aged
• Stomach Neoplasms (drug therapy, surgery)
• Tegafur (administration & dosage)
• Time Factors
• Tissue Distribution