In vivo anti-allergic and anti-inflammatory effects of drugs that inhibit lipoxygenase activity in vitro.

Abstract	Studies in vitro have already shown that the chemotactic effect of leukotriene LTB4, as well as its pro-aggregatory effect on a suspension of leukocytes, could be inhibited by the lipoxygenase (LO) inhibitor ETYA; moreover a beneficial effect of another LO-inhibitor, diethylcarbamazine, has been shown on experimental asthma. To explore a possible therapeutic application of substances that inhibit 15-LO of soybean in vitro, we have tested several active compounds, namely nordihydroguaiaretic acid (NDGA), phenidone, diethylcarbamazine and mefenamic acid, on the following in vivo inflammation models in the rat: plantar oedema induced by carrageenin; cutaneous vascular hyperpermeability induced by pafacether; pleurisy induced by carrageenin. The correlation between the LO-inhibitor effect of these compounds in vitro and their beneficial effects in the different tests that were performed, as well as the mechanisms of action induced in the different experimental models, are discussed.
Authors	A Etienne, C Soulard, C Touvay, F Clostre, P Braquet
Journal	International journal of tissue reactions (Int J Tissue React) Vol. 7 Issue 6 Pg. 459-62 ( 1985) ISSN: 0250-0868 [Print] Switzerland
PMID	3936815 (Publication Type: Journal Article)
Chemical References	Anti-Inflammatory Agents Anti-Inflammatory Agents, Non-Steroidal Catechols Lipoxygenase Inhibitors Organic Chemicals Pyrazoles Sulfides BM 15501 methyl-2-butylmercapto-4-catechol Masoprocol Dexamethasone Arachidonate Lipoxygenases phenidone Diethylcarbamazine Indomethacin
Topics	Animals Anti-Inflammatory Agents (pharmacology, therapeutic use) Anti-Inflammatory Agents, Non-Steroidal Arachidonate Lipoxygenases Capillary Permeability Catechols (pharmacology, therapeutic use) Dexamethasone (pharmacology, therapeutic use) Diethylcarbamazine (pharmacology, therapeutic use) Hypersensitivity (drug therapy, enzymology) In Vitro Techniques Indomethacin (pharmacology, therapeutic use) Inflammation (drug therapy, enzymology) Lipoxygenase Inhibitors Male Masoprocol Organic Chemicals Passive Cutaneous Anaphylaxis Pleurisy (drug therapy) Pyrazoles (pharmacology, therapeutic use) Rats Rats, Inbred Strains Sulfides

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