The antiinflammatory activity of the immunomodulator Wy-18,251 (3-(p-chlorophenyl)thiazolo[3,2-a]benzimidazole-2-acetic acid).

Abstract	The antiinflammatory activity of the immunomodulatory agent Wy-18,251 (3-(p-chlorophenyl)thiazolo-[3,2-a]benzimidazole-2-acetic acid) was examined using a variety of antiinflammatory, analgesic and antipyretic animal models in comparison to aspirin, levamisole and indomethacin. The acute antiinflammatory and analgesic activity of Wy-18,251 (ED50 = 100-200 mg/kg, p.o.) was similar to aspirin, but in contrast to aspirin Wy-18,251 failed to demonstrate antipyretic activity. Wy-18,251 (10-100 mg/kg, p.o.) also inhibited chronic inflammatory responses in the adjuvant- and collagen-induced arthritis models. Wy-18,251 was a modest inhibitor of prostaglandin biosynthesis but did not inhibit either 5- or 15-lipoxygenase enzymes. Wy-18,251 (up to 480 mg/kg, p.o.) produced little gastrointestinal pathology in 16 h fasted rats. The combined immunomodulatory and antiinflammatory activity of Wy-18,251 suggests that this agent may have therapeutic promise in certain immunoinflammatory diseases including rheumatoid arthritis.
Authors	S C Gilman, R P Carlson, J Chang, A J Lewis
Journal	Agents and actions (Agents Actions) Vol. 17 Issue 1 Pg. 53-9 (Oct 1985) ISSN: 0065-4299 [Print] Switzerland
PMID	3936345 (Publication Type: Comparative Study, Journal Article)
Chemical References	Adjuvants, Immunologic Analgesics Anti-Inflammatory Agents Arachidonic Acids Benzimidazoles Arachidonic Acid Levamisole tilomisole Collagen Aspirin
Topics	Adjuvants, Immunologic (therapeutic use, toxicity) Analgesics Animals Anti-Inflammatory Agents (therapeutic use, toxicity) Arachidonic Acid Arachidonic Acids (metabolism) Arthritis, Experimental (drug therapy, etiology) Aspirin (therapeutic use) Benzimidazoles (therapeutic use, toxicity) Collagen Fever (drug therapy, etiology) Gastric Mucosa (drug effects) Hyperesthesia (drug therapy) Inflammation (chemically induced, drug therapy) Levamisole (therapeutic use) Male Mice Mice, Inbred Strains Rats Rats, Inbred Lew Rats, Inbred Strains

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