Long-term ambulatory treatment of metastatic colorectal adenocarcinoma by continuous intravenous infusion of 5-fluorouracil.

• Abstract: To delineate the efficacy of continuous intravenous 5-fluorouracil (5-FU) infusion therapy for advanced colorectal adenocarcinoma, a study of 36 patients with measurable metastatic disease was conducted. Patients received a daily intravenous infusion of 300 mg/m2 5-FU over a 24-h period utilizing portable infusion devices and central venous catheters. In a population characterized by substantial pretreatment exposure to radiotherapy, chemotherapy, and other indicators of poor prognosis, 13/36 (36%) patients achieved an objective response. An additional 10/36 (28%) patients manifested stable disease (no change) and experienced survival comparable to that of patients with objective response. Toxicity was minimal; patients were able to continue 5-FU infusions 95% of the total time on protocol. There were no adverse hematologic effects or catheter complications. Because previously untreated patients benefited more frequently (positive response, 50%), continuous intravenous infusion should be evaluated further as a primary modality option when 5-fluorouracil antitumor chemotherapy is contemplated.
• Authors: E Quebbeman, R Ausman, R Hansen, T Becker, G Caballero, P Ritch, D Jenkins, D Blake, L Tangen, W Schulte
• Journal: Journal of surgical oncology (J Surg Oncol) Vol. 30 Issue 1 Pg. 60-5 (Sep 1985) ISSN: 0022-4790 [Print] UNITED STATES
• PMID: 3935873 (Publication Type: Journal Article)

Chemical References

• Fluorouracil

Topics

• Adenocarcinoma (drug therapy)
• Adult
• Aged
• Ambulatory Care
• Colonic Neoplasms (drug therapy, secondary)
• Female
• Fluorouracil (therapeutic use)
• Humans
• Infusions, Parenteral
• Long-Term Care
• Male
• Middle Aged
• Rectal Neoplasms (drug therapy, secondary)