[Hypercalcemia with elevation of parathormone in lymphocytic lymphoma. Efficacy of ethanehydroxydiphosphonate by mouth].

Abstract

Acute hypercalcaemia was observed in a 54 year old woman followed up over a five year period for a lymphocytic non-Hodgkin lymphoma, a complication which is rare in chronic lymphoproliferative disorders except multiple myeloma. This case is of interest from 3 points of view: haematological: the simultaneous occurrence of hypercalcaemia (4.80 mmol/l) and of a leukaemic phase (19,300 lymphocytes/mm3) with no signs of "transformation" of the haemopathy; physiopathological: increased osteoclastic bone resorption and a rise in serum parathormone (0.21 to 4.82 ng/ml); therapeutic: efficacy of oral ethane 1, hydroxy 1, 1 diphosphonate (20 mg/kg/day) in treating the hypercalcaemia.

• Authors: B Desablens, J L Sebert, J F Claisse, A Pruna, A Marié, J Delobel, J Messerschmitt
• Journal: Annales de medecine interne (Ann Med Interne (Paris)) Vol. 136 Issue 2 Pg. 114-20 ( 1985) ISSN: 0003-410X [Print] France
• Vernacular Title: Hypercalcémie avec élévation de la parathormone au cours d'un lymphome lymphocytique. Efficacité de l'éthane 1, hydroxy 1, 1 diphosphonate per os.
• PMID: 3935022 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Parathyroid Hormone
• Phosphates
• Etidronic Acid

Topics

• Bone Resorption
• Etidronic Acid (therapeutic use)
• Female
• Humans
• Hypercalcemia (complications, drug therapy, physiopathology)
• Lymphocytes (pathology)
• Lymphoma (blood, complications)
• Middle Aged
• Osteoclasts (physiology)
• Parathyroid Hormone (blood)
• Phosphates (blood)