Ability of sera from mice treated with Ge-132, an organic germanium compound, to inhibit experimental murine ascites tumours.

Abstract

Sera from C57Bl/6 mice treated orally with Ge-132 exhibited antitumour activity against Ehrlich (allogeneic) and RL male 1 (syngeneic) ascites tumours in BALB/c mice. Sera obtained from mice 24 h after Ge-132 administration displayed the greatest antitumour effect and this was dose dependent. Sera prepared from mice 12, 36, or 48 h after Ge-132 treatment had no protective effect. Circulating interferon (IFN) was induced at 24 h after administration of Ge-132 but was not detected in the sera at 12, 36, or 48 h after administration. The antiviral activity of sera from Ge-132-treated mice was inactivated by treatments with trypsin, low pH, and anti-IFN gamma antiserum. The inactivated preparations of serum IFN induced by Ge-132 did not exhibit antitumour activity when administered to tumour-bearing mice. These results suggest that antitumour activity in the sera of Ge-132-treated mice may be expressed through activities of Ge-132-induced lymphokine(s), such as IFN gamma.

• Authors: F Suzuki, R R Brutkiewicz, R B Pollard
• Journal: British journal of cancer (Br J Cancer) Vol. 52 Issue 5 Pg. 757-63 (Nov 1985) ISSN: 0007-0920 [Print] England
• PMID: 3933536 (Publication Type: Journal Article)

Chemical References

• Organometallic Compounds
• Propionates
• Germanium
• propagermanium
• Interferon-gamma

Topics

• Animals
• Carcinoma, Ehrlich Tumor (therapy)
• Dose-Response Relationship, Immunologic
• Female
• Germanium (pharmacology)
• Interferon-gamma (antagonists & inhibitors, blood)
• Male
• Mice
• Mice, Inbred BALB C
• Mice, Inbred C57BL
• Neoplasms, Experimental (mortality, therapy)
• Organometallic Compounds (pharmacology)
• Propionates
• Time Factors