Biotinidase deficiency: a novel vitamin recycling defect.

Abstract	The recent finding that biotinidase deficiency is the primary biochemical defect in late-onset multiple carboxylase deficiency was stimulated new interest in the inherited disorders of biotin-dependent carboxylases. The clinical and biochemical features of biotinidase deficiency are discussed. We also speculate about two exciting areas currently being investigated: the localization of action biotinidase, and the possible role of the enzyme as a binding or carrier protein for biotin.
Authors	B Wolf, R E Grier, J R Secor McVoy, G S Heard
Journal	Journal of inherited metabolic disease (J Inherit Metab Dis) Vol. 8 Suppl 1 Pg. 53-8 ( 1985) ISSN: 0141-8955 [Print] United States
PMID	3930841 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S., Review)
Chemical References	Carrier Proteins biotin-binding proteins Biotin Amidohydrolases Biotinidase
Topics	Adult Amidohydrolases (blood, deficiency, physiology) Biotin (metabolism) Biotinidase Carrier Proteins (physiology) Female Humans Infant, Newborn Pregnancy Prenatal Diagnosis

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