Increased radiosensitivity of tumors by perfluorochemicals and carbogen.

Abstract

The efficacy of an emulsion of perfluorochemicals (Fluosol-DA) to sensitize RIF-1 tumors of C3H mice to radiation was studied. An i.v. injection of 12 ml/kg of Fluosol-DA (20%) to tumor-bearing animals and keeping the animals in an atmosphere of a mixture of O2 (95%) and CO2 (5%) (carbogen) for 1 hr before and during irradiation of s.c. tumors in the thigh significantly enhanced the tumoricidal effect of radiation as measured with growth delay of the treated tumors. A lesser but significant enhancement of radiation damage in the tumors was also observed when the animals were kept in carbogen for 1 hr without injection of Fluosol-DA. It was concluded that Fluosol-DA increased the delivery of oxygen to hypoxic areas in the tumors and enhanced the response of hypoxic cells to radiation.

• Authors: C W Song, W L Zhang, D M Pence, I Lee, S H Levitt
• Journal: International journal of radiation oncology, biology, physics (Int J Radiat Oncol Biol Phys) Vol. 11 Issue 10 Pg. 1833-6 (Oct 1985) ISSN: 0360-3016 [Print] United States
• PMID: 3930442 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Drug Combinations
• Fluorocarbons
• Hydroxyethyl Starch Derivatives
• Radiation-Sensitizing Agents
• Carbon Dioxide
• glucose, glycerol, hydroxyethyl starch, perfluorodecalin, perfluorotripropylamine, pluronic F-68, salts, yolk phospholipids drug combination
• carbogen
• Oxygen

Topics

• Animals
• Carbon Dioxide (administration & dosage)
• Drug Combinations (administration & dosage)
• Fluorocarbons (administration & dosage)
• Hydroxyethyl Starch Derivatives
• Mice
• Mice, Inbred C3H
• Neoplasms, Experimental (radiotherapy)
• Oxygen (administration & dosage)
• Radiation-Sensitizing Agents