Low susceptibility of analbuminemic rats to induction of bladder cancer by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide.

Abstract

The susceptibility of analbuminemic rats (Nagase analbuminemic rats; NAR) to induction of bladder cancer by oral N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide (FANFT) was studied. Male NAR and Sprague-Dawley rats (SD) were fed normal diet or normal diet supplemented with 0.2% FANFT for 10 weeks and killed in week 52. Bladder cancer was found in 5 of 24 SD (21%) but not in 18 NAR (0%). Proliferative lesions of the bladder epithelium, which are considered to be precancerous or more advanced than precancerous changes, were found in 16 of 24 SD (67%), but in only 4 of 18 NAR (22%). NAR showed lower susceptibility than control SD to induction of bladder cancer by FANFT.

• Authors: Y Hosaka, M Muramatsu, T Matsushima, T Niijima, S Nagase
• Journal: Japanese journal of cancer research : Gann (Jpn J Cancer Res) Vol. 76 Issue 7 Pg. 577-82 (Jul 1985) ISSN: 0910-5050 [Print] Japan
• PMID: 3928553 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Serum Albumin
• Thiazoles
• FANFT

Topics

• Animals
• FANFT
• Hyperlipidemias (genetics)
• Male
• Rats
• Rats, Inbred Strains
• Rats, Mutant Strains
• Serum Albumin (deficiency)
• Thiazoles
• Urinary Bladder Neoplasms (chemically induced, genetics)