Abstract |
The susceptibility of analbuminemic rats ( Nagase analbuminemic rats; NAR) to induction of bladder cancer by oral N-[4-(5-nitro-2-furyl)-2-thiazolyl] formamide ( FANFT) was studied. Male NAR and Sprague-Dawley rats (SD) were fed normal diet or normal diet supplemented with 0.2% FANFT for 10 weeks and killed in week 52. Bladder cancer was found in 5 of 24 SD (21%) but not in 18 NAR (0%). Proliferative lesions of the bladder epithelium, which are considered to be precancerous or more advanced than precancerous changes, were found in 16 of 24 SD (67%), but in only 4 of 18 NAR (22%). NAR showed lower susceptibility than control SD to induction of bladder cancer by FANFT.
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Authors | Y Hosaka, M Muramatsu, T Matsushima, T Niijima, S Nagase |
Journal | Japanese journal of cancer research : Gann
(Jpn J Cancer Res)
Vol. 76
Issue 7
Pg. 577-82
(Jul 1985)
ISSN: 0910-5050 [Print] Japan |
PMID | 3928553
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Serum Albumin
- Thiazoles
- FANFT
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Topics |
- Animals
- FANFT
- Hyperlipidemias
(genetics)
- Male
- Rats
- Rats, Inbred Strains
- Rats, Mutant Strains
- Serum Albumin
(deficiency)
- Thiazoles
- Urinary Bladder Neoplasms
(chemically induced, genetics)
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