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Effect of teleocidin on immune responses in vitro.

Abstract
The effect of teleocidin, a new tumor promoter, on immune responses was studied in vitro using murine lymphocytes. Teleocidin had a mitogenic and a comitogenic activity on murine lymphocytes at doses of 1-1000 ng/ml. The responder cells to teleocidin stimulation were T cells. However, for the stimulation of T cells with teleocidin, Ia-positive macrophages were required as accessory cells. On the other hand, teleocidin had a suppressive activity at the same doses on the induction of hapten-reactive cytotoxic T cell response in vitro. All these results on mitogenic and immunosuppressive activity are similar to those obtained in a previous study on 12-O-tetradecanoyl phorbol-13-acetate. Thus, it is suggested that the role of tumor promoters during carcinogenesis is a potentiation of the growth of transformed cells and a suppression of the immune-surveillance mechanism.
AuthorsU Yamashita
JournalJapanese journal of cancer research : Gann (Jpn J Cancer Res) Vol. 76 Issue 6 Pg. 532-40 (Jun 1985) ISSN: 0910-5050 [Print] Japan
PMID3926584 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Carcinogens
  • Histocompatibility Antigens Class II
  • Lyngbya Toxins
  • teleocidins
Topics
  • Animals
  • Carcinogens (pharmacology)
  • Female
  • Histocompatibility Antigens Class II (immunology)
  • Immunity (drug effects)
  • Immunosuppression Therapy
  • Lymphocyte Activation
  • Lyngbya Toxins (pharmacology)
  • Macrophages (drug effects)
  • Male
  • Mice
  • Mice, Inbred Strains
  • T-Lymphocytes (drug effects)
  • T-Lymphocytes, Cytotoxic (drug effects)

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