Abstract |
The effect of teleocidin, a new tumor promoter, on immune responses was studied in vitro using murine lymphocytes. Teleocidin had a mitogenic and a comitogenic activity on murine lymphocytes at doses of 1-1000 ng/ml. The responder cells to teleocidin stimulation were T cells. However, for the stimulation of T cells with teleocidin, Ia-positive macrophages were required as accessory cells. On the other hand, teleocidin had a suppressive activity at the same doses on the induction of hapten-reactive cytotoxic T cell response in vitro. All these results on mitogenic and immunosuppressive activity are similar to those obtained in a previous study on 12-O-tetradecanoyl phorbol-13-acetate. Thus, it is suggested that the role of tumor promoters during carcinogenesis is a potentiation of the growth of transformed cells and a suppression of the immune-surveillance mechanism.
|
Authors | U Yamashita |
Journal | Japanese journal of cancer research : Gann
(Jpn J Cancer Res)
Vol. 76
Issue 6
Pg. 532-40
(Jun 1985)
ISSN: 0910-5050 [Print] Japan |
PMID | 3926584
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Carcinogens
- Histocompatibility Antigens Class II
- Lyngbya Toxins
- teleocidins
|
Topics |
- Animals
- Carcinogens
(pharmacology)
- Female
- Histocompatibility Antigens Class II
(immunology)
- Immunity
(drug effects)
- Immunosuppression Therapy
- Lymphocyte Activation
- Lyngbya Toxins
(pharmacology)
- Macrophages
(drug effects)
- Male
- Mice
- Mice, Inbred Strains
- T-Lymphocytes
(drug effects)
- T-Lymphocytes, Cytotoxic
(drug effects)
|