HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Fetal diabetes in rats and its effect on placental glycogen.

Abstract
The role of fetal insulin in placental glycogen accumulation, which occurs despite insulin deficiency in maternal diabetes, was studied in rats. Streptozotocin was injected into fetuses of non-diabetic and streptozotocin-diabetic mothers on days 19.5 and 20.5 of gestation, causing fetal hypoinsulinaemia and pancreatic insulin depletion. Placental glycogen content of either 1.6 mg/g in non-diabetic rats or 6.5 mg/g in diabetic rats was not affected by fetal streptozotocin treatment. Glycogen distribution was also measured in the placenta to assess the effect of fetal hypoinsulinaemia on glycogen content in its fetal segment. The glycogen concentration ratio between the fetal and maternal segments in diabetic rats was approximately 0.3 and increased to approximately 0.5 in diabetic rats, without being affected by fetal hypoinsulinaemia. There was no significant effect of fetal hypoinsulinaemia on the activities of placental glycogen synthase or glycogen phosphorylase, both in non-diabetic and diabetic rats. Fetal hypoinsulinaemia was associated, however, with a marked decrease in fetal liver glycogen together with a decrease in fetal liver weight, which was more pronounced than the decrease in fetal body weight. Administration of insulin to the streptozotocin-treated fetuses restored the impaired glycogen synthesis (measured by incorporation of U-[14C]-glucose and 3H2O in the fetal liver) without affecting glycogen synthesis in the placenta.(ABSTRACT TRUNCATED AT 250 WORDS)
AuthorsV Barash, A Gutman, E Shafrir
JournalDiabetologia (Diabetologia) Vol. 28 Issue 4 Pg. 244-9 (Apr 1985) ISSN: 0012-186X [Print] Germany
PMID3926571 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Insulin
  • Liver Glycogen
  • Glycogen
  • Phosphorylases
  • Glycogen Synthase
  • Glucose
Topics
  • Animals
  • Diabetes Mellitus, Experimental (metabolism)
  • Female
  • Glucose (metabolism)
  • Glycogen (analysis, metabolism)
  • Glycogen Synthase (metabolism)
  • Insulin (metabolism, pharmacology, physiology)
  • Liver Glycogen (metabolism)
  • Organ Size (drug effects)
  • Pancreas (metabolism)
  • Phosphorylases (metabolism)
  • Placenta (metabolism)
  • Pregnancy
  • Rats

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: