Effect of coenzyme-A, NAD, alpha lipoic-acid and cocarboxylase on survival of rats with galactosamine-induced severe hepatitis.

Abstract

Galactosamine, a selective hepatotoxin, produces in rats histologic alterations, which show the characteristics of severe human viral hepatitis. In the present study the efficacy of two different cofactor regimens (coenzyme A, NAD, alpha lipoic-acid, cocarboxylase) in rats with fulminant galactosamine hepatitis were tested. The results showed an improvement of the short-term survival with a short-term treatment and definitely better survival with a long-term regimen with cofactors.

• Authors: H Thölen, W Zimmerli, Z Rajacic
• Journal: Experientia (Experientia) Vol. 41 Issue 8 Pg. 1042-5 (Aug 15 1985) ISSN: 0014-4754 [Print] Switzerland
• PMID: 3926531 (Publication Type: Journal Article)

Chemical References

• NAD
• Thioctic Acid
• Galactosamine
• Thiamine Pyrophosphate
• Coenzyme A

Topics

• Animals
• Coenzyme A (therapeutic use)
• Disease Models, Animal
• Female
• Galactosamine
• Hepatitis (drug therapy, etiology)
• Liver Function Tests
• NAD (therapeutic use)
• Rats
• Rats, Inbred Strains
• Thiamine Pyrophosphate (therapeutic use)
• Thioctic Acid (therapeutic use)