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Effects of tiapride in tardive dyskinesia.

Abstract
Tiapride, a selective D2 dopaminergic receptor blocking agent from the substituted benzamide class, was evaluated in a blind video-controlled trial in 10 psychiatric patients with tardive dyskinesia. There was a significant decrease in dyskinesia with a parallel increase in parkinsonism. This relationship between two opposite effects on movement suggests a common pathophysiological basis lying on a reciprocal hyper- and hypoactivity of the dopaminergic striatal system. Nevertheless, other mechanisms may be involved, for the evolution of individual parkinsonian and dyskinesia scores is not necessarily opposite: the tiapride-induced parkinsonism was generally acceptable and in two cases, the dyskinesia scores were reduced without an increase in parkinsonism. Therefore, more dyskinetic patients have to be evaluated in long-term studies with tiapride, before this drug could be recommended in tardive dyskinesia, when dyskinetic movements become intolerable.
AuthorsP Pollak, J M Gaio, M Hommel, J Pellat, J Perret
JournalPsychopharmacology (Psychopharmacology (Berl)) Vol. 85 Issue 2 Pg. 236-9 ( 1985) ISSN: 0033-3158 [Print] Germany
PMID3925489 (Publication Type: Clinical Trial, Journal Article)
Chemical References
  • Benzamides
  • Tiapamil Hydrochloride
Topics
  • Adult
  • Aged
  • Benzamides (therapeutic use)
  • Clinical Trials as Topic
  • Dyskinesia, Drug-Induced (drug therapy)
  • Female
  • Humans
  • Male
  • Middle Aged
  • Parkinson Disease, Secondary (chemically induced)
  • Tiapamil Hydrochloride (adverse effects, therapeutic use)

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