[Management of acute gonorrhea in males with Rosoxacin].

Abstract

A single dose of 300 mg of the quinoline carbonic acid derivative rosoxazin (Winuron) was used for treatment of 59 men with uncomplicated gonorrhoea and two males with fresh infection with penicillin-resistant gonococci. Within 48 hours full clinical remission was seen in all 61 cases confirmed bacteriologically for gonococci. Concomitant infection with other pathogens transmitted by intercourse, present in 69% of cases, could not be influenced or changed by this treatment. Tolerance was good: 21 patients (32%) complained of slight side effects, however, only 3 patients (5%) showed significant central nervous or gastrointestinal symptoms. Rosoxazin has the great advantage of reliable effectiveness even in case of penicillin-resistant gonococci. Thus, the substance offers an effective and well-tolerated orally applicable and reasonably priced alternative to conventional treatment of gonorrhoea.

• Authors: U Fischer-Brügge, D Reinel
• Journal: Deutsche medizinische Wochenschrift (1946) (Dtsch Med Wochenschr) Vol. 110 Issue 28-29 Pg. 1115-8 (Jul 12 1985) ISSN: 0012-0472 [Print] Germany
• Vernacular Title: Behandlung der akuten Gonorrhoe des Mannes mit Rosoxacin.
• PMID: 3924547 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• 4-Quinolones
• Anti-Infective Agents
• Quinolines
• Quinolones
• rosoxacin

Topics

• 4-Quinolones
• Adolescent
• Adult
• Anti-Infective Agents
• Clinical Trials as Topic
• Drug Evaluation
• Gonorrhea (drug therapy)
• Humans
• Male
• Neisseria gonorrhoeae (drug effects)
• Penicillin Resistance
• Quinolines (therapeutic use)
• Quinolones