HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

A possible beneficial effect of metronidazole in reducing TPN-associated liver function derangements.

Abstract
Cholestasis and fatty infiltration of the liver are common complications of total parenteral nutrition (TPN). Following a recent suggestion that TPN-associated liver function derangements may be related to intestinal overgrowth of anaerobic bacteria, the effect of metronidazole on hepatic dysfunction during TPN in rats was investigated. After 5 days of TPN with either amino acids and glucose or amino acids with glucose and fat, all groups exhibited a mild weight gain, positive nitrogen balance, increased liver weight, increased liver:body weight ratio, increased levels of liver enzymes, and increased hepatic lipid content. The administration of metronidazole at 15 mg/kg/day significantly decreased the hepatic lipid content from 0.077 g fat/g liver for controls to 0.053 g fat/g liver. The efficacy of metronidazole in reducing hepatic fat accumulation during nutritionally effective and adequate TPN in rats suggests the possible involvement of anaerobic bacterial flora of the intestinal tract, at least in part, in the pathogenesis of TPN-associated liver function derangements. However, the various biochemical and morphological expressions of these changes and the discrepancy between unchanged liver weight, liver:body weight ratio, liver enzymes, and the improved hepatic fat content suggest multifactorial mechanisms for TPN-related liver damage.
AuthorsH R Freund, M Muggia-Sullam, R LaFrance, E B Enrione, M B Popp, H S Bjornson
JournalThe Journal of surgical research (J Surg Res) Vol. 38 Issue 4 Pg. 356-63 (Apr 1985) ISSN: 0022-4804 [Print] United States
PMID3923267 (Publication Type: Journal Article)
Chemical References
  • Amino Acids
  • Lipids
  • Metronidazole
Topics
  • Amino Acids (administration & dosage, blood)
  • Animals
  • Bacteria (growth & development)
  • Cholestasis, Intrahepatic (prevention & control)
  • Fatty Liver (prevention & control)
  • Injections, Intravenous
  • Intestines (microbiology)
  • Lipids (analysis)
  • Liver (enzymology, metabolism, pathology)
  • Liver Diseases (prevention & control)
  • Liver Function Tests
  • Male
  • Metronidazole (administration & dosage, therapeutic use)
  • Organ Size
  • Parenteral Nutrition (adverse effects)
  • Parenteral Nutrition, Total (adverse effects)
  • Rats

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: