[Pathologo-anatomical characteristics of hyperosmolar and other comatous conditions].

Abstract

Fifty-four cases of death from hyperosmolar comas were examined pathoanatomically together with the postmortem biochemical analysis of the CSF and blood. Brain of animals with disturbances of the blood and CSF osmolarity was studied electron cytochemically and autoradiographically. It was discovered that the hyperosmolar comas are manifested by excosis and brain collapse. The brain is reduced in volume due to deep cell-extracell dehydration and alteration of the hematoencephalic barrier with the irreversible depression of the neuronal and glial metabolism. In 7 patients dying with the purulent-necrotic changes of vessels resulting from the hyperosmolar effect of verografin used for the carotid angiography, numerous perivascular hemorrhages developed in the brain. Dysequilibrium syndrome in hemodialysis is manifested by an acute brain swelling or by a formation at a later period of symmetrical ischemic-hemorrhagic necrosis in the thalamus and occipital lobes of the large hemispheres.

• Authors: V A Tumanskiĭ
• Journal: Arkhiv patologii (Arkh Patol) Vol. 47 Issue 2 Pg. 51-8 ( 1985) ISSN: 0004-1955 [Print] Russia (Federation)
• Vernacular Title: Patologoanatomicheskaia kharakteristika giperosmoliarnykh i drugikh komatoznykh sostoianiĭ.
• PMID: 3922335 (Publication Type: English Abstract, Journal Article)

Chemical References

• Contrast Media
• Mannitol

Topics

• Animals
• Brain (pathology, ultrastructure)
• Cats
• Cerebral Angiography (adverse effects)
• Contrast Media (adverse effects)
• Dehydration (etiology, pathology)
• Diabetic Coma (pathology)
• Humans
• Hyperglycemic Hyperosmolar Nonketotic Coma (etiology, pathology)
• Mannitol (adverse effects)
• Microscopy, Electron
• Rabbits
• Rats