[Behavior of the concentration of triiodothyronine, thyroxine, thyrotropin and thyroxine-binding globulin in the serum of children with nephrotic syndrome].

Abstract

Concentrations of triiodothyronine, thyroxine, thyrotropin, thyroxine-binding globulin, urea, creatinine, cholesterol and total protein were determined in serum of six children (ages from 4 to 16 years) with nephrotic syndrome undergoing therapy. The results showed that with decreasing concentration of serum protein and increasing concentration of cholesterol the concentrations of thyroxine and thyroxine-binding globulin decreased whereas the concentration of thyrotropin was elevated. Improvement in the concentration of serum protein lead to an improvement of serum levels of thyroid hormones and thyroxine-binding globulin; concentrations of thyrotropin and cholesterol returned to values close to normal. Although triiodothyronine was decreased slightly it remained in the normal range thus preventing overt hypothyroidism.

• Authors: N Liappis, G S Rao
• Journal: Klinische Padiatrie (Klin Padiatr) 1985 Jan-Feb Vol. 197 Issue 1 Pg. 35-9 ISSN: 0300-8630 [Print] Germany
• Vernacular Title: Verhalten der Konzentration von Trijodthyronin, Thyroxin, Thyreotropin und thyroxin-bindendem Globulin im Serum von Kindern mit nephrotischem Syndrom.
• PMID: 3919201 (Publication Type: English Abstract, Journal Article)

Chemical References

• Blood Proteins
• Thyroxine-Binding Proteins
• Triiodothyronine
• Thyrotropin
• Cholesterol
• Creatinine
• Thyroxine

Topics

• Adolescent
• Blood Proteins (metabolism)
• Blood Urea Nitrogen
• Child
• Child, Preschool
• Cholesterol (blood)
• Creatinine (blood)
• Female
• Humans
• Male
• Nephrotic Syndrome (blood)
• Thyrotropin (blood)
• Thyroxine (blood)
• Thyroxine-Binding Proteins (metabolism)
• Triiodothyronine (blood)