Reciprocal biological activities of the cyclic tetrapeptides chlamydocin and HC-toxin.

Abstract

Chlamydocin, a potent cytostatic agent against cultured mammalian cells, and HC-toxin, a host-specific phytotoxin, are cyclic tetrapeptides containing the same epoxide alpha-amino acid. We show here that these compounds have reciprocal biological activity; HC-toxin is cytostatic against cultured mastocytoma cells, and chlamydocin has host-specific toxin activity against maize. Chlamydocin and another related cyclic peptide, Cyl-2, are less host-specific than HC-toxin because maize tolerant to HC-toxin is more sensitive to chlamydocin and Cyl-2.

• Authors: J D Walton, E D Earle, H Stähelin, A Grieder, A Hirota, A Suzuki
• Journal: Experientia (Experientia) Vol. 41 Issue 3 Pg. 348-50 (Mar 15 1985) ISSN: 0014-4754 [Print] Switzerland
• PMID: 3918884 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibiotics, Antineoplastic
• Peptides, Cyclic
• Toxins, Biological
• chlamydocin
• HC toxin

Topics

• Animals
• Antibiotics, Antineoplastic
• Cell Cycle (drug effects)
• Cells, Cultured
• Kinetics
• Mast-Cell Sarcoma (pathology)
• Mitosis (drug effects)
• Peptides, Cyclic (pharmacology)
• Plant Development
• Plants (drug effects)
• Toxins, Biological
• Zea mays