Fever of unexplained origin, biochemical Cushing's disease and cerebral dysrhythmia corrected by valproate sodium.

Abstract

A patient with cerebral dysrhythmia and fever of unexplained origin for 2 years is described. She had elevated and nonsuppressible levels of urinary 17-hydroxycorticosteroids but no clinical features of hypercortisolism. Treatment with valproate sodium corrected all the abnormalities. It is postulated that cerebral dysrhythmia can affect the hypothalamic mechanisms of body temperature and regulation of adrenocorticotropic hormone levels.

• Authors: J M López-Moreno, J A Rodríguez-Portales, D Mahana
• Journal: Canadian Medical Association journal (Can Med Assoc J) Vol. 132 Issue 2 Pg. 150-4 (Jan 15 1985) ISSN: 0008-4409 [Print] Canada
• PMID: 3917350 (Publication Type: Case Reports, Journal Article)

Chemical References

• Valproic Acid

Topics

• Adult
• Brain (physiopathology)
• Cushing Syndrome (drug therapy, physiopathology)
• Electroencephalography
• Female
• Fever of Unknown Origin (drug therapy, physiopathology)
• Humans
• Valproic Acid (therapeutic use)