Comparative study of desoximetasone ointment 0.25% versus fluocinonide ointment 0.05% in patients with psoriasis.

Abstract

In a multicenter, investigator-blind study, desoximetasone ointment 0.25% was compared with fluocinonide ointment 0.05% in the treatment of patients with psoriasis. Evaluations were made before treatment and after 4, 7, and 14 days of treatment. Both drugs were shown to be safe and effective. Desoximetasone was significantly superior to fluocinonide in improving severity scores from baseline for thickening (days 7 and 14) and erythema (day 14); in numbers of subjects cleared of thickening (day 4); in overall evaluation ratings as compared to baseline (day 14); and in number of patients receiving an overall evaluation of excellent. No side effects were reported for either treatment group during the study.

• Journal: Clinical therapeutics (Clin Ther) Vol. 8 Issue 1 Pg. 118-25 ( 1985) ISSN: 0149-2918 [Print] United States
• PMID: 3914368 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)

Chemical References

• Ointments
• Fluocinolone Acetonide
• Fluocinonide
• Desoximetasone
• Dexamethasone

Topics

• Adolescent
• Adult
• Aged
• Child
• Child, Preschool
• Clinical Trials as Topic
• Desoximetasone (administration & dosage, therapeutic use)
• Dexamethasone (analogs & derivatives)
• Female
• Fluocinolone Acetonide (analogs & derivatives)
• Fluocinonide (administration & dosage, therapeutic use)
• Humans
• Male
• Middle Aged
• Ointments
• Psoriasis (drug therapy)
• Random Allocation