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Nortriptyline and fluphenazine in the symptomatic treatment of diabetic neuropathy. A double-blind cross-over study.

Abstract
A controlled clinical trial on the efficacy of a nortriptyline-fluphenazine combination was carried out in patients with painful diabetic polyneuropathy. A visual analog scale was used to evaluate the relief of pain or paresthesia. Significant relief of both pain and paresthesia was obtained with this combination. The differences were statistically significant. Side effects were frequent but not usually severe enough to lead to cessation of these medications.
AuthorsFrancisco J Gomez-Perez, Juan A Rull, Haroldo Dies, Guillermo J Rodriguez-Rivera, Jorge Gonzalez-Barranco, Oscar Lozano-Castañeda
JournalPain (Pain) Vol. 23 Issue 4 Pg. 395-400 (Dec 1985) ISSN: 0304-3959 [Print] United States
PMID3911140 (Publication Type: Clinical Trial, Journal Article)
Chemical References
  • Nortriptyline
  • Fluphenazine
Topics
  • Adult
  • Aged
  • Clinical Trials as Topic
  • Diabetic Neuropathies (complications, drug therapy)
  • Double-Blind Method
  • Female
  • Fluphenazine (adverse effects, therapeutic use)
  • Humans
  • Male
  • Middle Aged
  • Nortriptyline (adverse effects, therapeutic use)
  • Pain (drug therapy, etiology)
  • Paresthesia (drug therapy, etiology)

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