A multi-centre general practice clinical evaluation of pivmecillinam plus pivampicillin ('Miraxid') and co-trimoxazole ('Septrin') in respiratory tract infections.

Abstract	Seven-day courses of either 200 mg pivmecillinam plus 250 mg pivampicillin or co-trimoxazole (800 mg sulphamethoxazole plus 160 mg trimethoprim) given twice daily were compared in a multi-centre general practice study in 318 patients with signs and symptoms of upper or lower respiratory tract infection. Patients were stratified into four diagnostic groups (sinusitis, otitis media, throat infections, and acute bronchitis) and randomly allocated to treatment within these groups. Assessments at Day 7 showed that both treatments were equally effective clinically, 154 (91%) patients in the pivmecillinam plus pivampicillin group showing clinical cure or improvement and 142 (88%) patients in the co-trimoxazole group. Side-effects were reported by 19 (11.9%) patients in the pivmecillinam plus pivampicillin group and by 24 (15.8%) patients in the co-trimoxazole group. Two patients in the pivmecillinam plus pivampicillin group and 4 patients in the co-trimoxazole group stopped treatment.
Authors	R B Wallace, B T Marsh, D J Talbot
Journal	Current medical research and opinion (Curr Med Res Opin) Vol. 9 Issue 10 Pg. 659-65 ( 1985) ISSN: 0300-7995 [Print] England
PMID	3907987 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
Chemical References	Anti-Infective Agents Drug Combinations Pivampicillin Amdinocillin Pivoxil Ampicillin Trimethoprim, Sulfamethoxazole Drug Combination Trimethoprim Sulfamethoxazole Amdinocillin
Topics	Adolescent Adult Aged Amdinocillin (therapeutic use) Amdinocillin Pivoxil (therapeutic use) Ampicillin (analogs & derivatives) Anti-Infective Agents (therapeutic use) Bronchitis (drug therapy) Child Clinical Trials as Topic Drug Combinations (therapeutic use) Family Practice Female Humans Male Middle Aged Otitis Media (drug therapy) Pharyngitis (drug therapy) Pivampicillin (therapeutic use) Random Allocation Respiratory Tract Infections (drug therapy) Sinusitis (drug therapy) Sulfamethoxazole (therapeutic use) Trimethoprim (therapeutic use) Trimethoprim, Sulfamethoxazole Drug Combination

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