Comparative clinical evaluation of ceftizoxime with clindamycin and gentamicin and cefoxitin in the treatment of postcesarean endomyometritis.

New third generation cephalosporins have been recommended as single agent antibiotic therapy in the treatment of postoperative infections. This study compares the new third generation cephalosporin ceftizoxime with cefoxitin, clindamycin and gentamicin in the treatment of postcesarean section endomyometritis. The results indicate that the clindamycin and gentamicin regimen is more efficacious in the treatment of severe infection after cesarean section than either ceftizoxime or cefoxitin regimens. Therefore, the results of this study suggest caution in substituting single drug antibiotic therapy with cefoxitin or the third generation cephalosporins for the standard clindamycin and gentamicin regimen in the treatment of postcesarean section endomyometritis until more clinical data are available.
AuthorsJ J Apuzzio, V Ganesh, M A Pelosi, I Landau, H A Kaminetzky, Z Kaminski, D B Louria
JournalSurgery, gynecology & obstetrics (Surg Gynecol Obstet) Vol. 161 Issue 6 Pg. 518-22 (Dec 1985) ISSN: 0039-6087 [Print] UNITED STATES
PMID3906971 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Gentamicins
  • Clindamycin
  • Cefoxitin
  • Ceftizoxime
  • Cefotaxime
  • Adult
  • Cefotaxime (administration & dosage, analogs & derivatives)
  • Cefoxitin (administration & dosage)
  • Ceftizoxime
  • Cervix Uteri (microbiology)
  • Cesarean Section
  • Clindamycin (administration & dosage)
  • Drug Therapy, Combination
  • Endometritis (drug therapy, microbiology)
  • Escherichia coli (isolation & purification)
  • Female
  • Gentamicins (administration & dosage)
  • Humans
  • Postoperative Complications (drug therapy)
  • Pregnancy
  • Streptococcus agalactiae (isolation & purification)
  • Streptococcus pyogenes (isolation & purification)

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