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Effect of Plasmodium berghei infection on benzoic acid metabolism in mice.

Abstract
The metabolism of benzoic acid was studied in Plasmodium berghei infected mice both in vitro and in vivo. Results of in vitro studies showed a considerable decrease in the ability of the infected liver to detoxify benzoic acid by hippuric acid formation. The in vivo study showed that hippuric acid formation decreases with increasing parasitemia and the emergence of benzoyl-glucuronide. This new pathway stops operating with further increase in parasitemia.
AuthorsT S Emudianughe, Q D Bickle, M G Taylor, B Andrews
JournalExperientia (Experientia) Vol. 41 Issue 11 Pg. 1407-9 (Nov 15 1985) ISSN: 0014-4754 [Print] Switzerland
PMID3905430 (Publication Type: Journal Article)
Chemical References
  • Benzoates
  • Hippurates
  • benzoyl glucuronide
  • Benzoic Acid
  • hippuric acid
Topics
  • Animals
  • Benzoates (metabolism, urine)
  • Benzoic Acid
  • Hippurates (metabolism, urine)
  • Kinetics
  • Liver (metabolism)
  • Malaria (metabolism)
  • Male
  • Mice
  • Plasmodium berghei

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