Fat embolism and osteonecrosis.

Clinical and experimental data accumulated within the past 2 decades explain the relationship between fat embolism and osteonecrosis, which now appears to be more causal than coincidental. Evidence for fatty liver, coalescence of endogenous plasma lipoproteins, and/or disruption of depot or marrow fat, all resulting in continuous or intermittent fat embolism, is related to 13 different clinical conditions associated with osteonecrosis, most recently including pregnancy, carbon tetrachloride poisoning, and possibly Legg-Calvé-Perthes disease. Intraosseous fat embolism, then, appears to trigger a three-phase thrombotic process of focal intravascular coagulation that results in osteonecrosis.
AuthorsJ P Jones Jr
JournalThe Orthopedic clinics of North America (Orthop Clin North Am) Vol. 16 Issue 4 Pg. 595-633 (Oct 1985) ISSN: 0030-5898 [Print] UNITED STATES
PMID3903602 (Publication Type: Case Reports, Journal Article, Review)
Chemical References
  • Adrenal Cortex Hormones
  • Hydrocarbons, Halogenated
  • Lipoproteins
  • Adrenal Cortex Hormones (adverse effects)
  • Alcoholism (complications)
  • Animals
  • Bone and Bones (blood supply)
  • Child
  • Decompression Sickness (complications)
  • Embolism, Fat (complications, physiopathology)
  • Fatty Liver (physiopathology)
  • Female
  • Femur Head Necrosis (etiology)
  • Gaucher Disease (complications)
  • Hemoglobinopathies (complications)
  • Humans
  • Hydrocarbons, Halogenated (poisoning)
  • Hyperlipidemias (physiopathology)
  • Legg-Calve-Perthes Disease (etiology)
  • Lipoproteins (blood)
  • Male
  • Middle Aged
  • Obesity (complications)
  • Osteonecrosis (etiology, physiopathology)
  • Pancreatitis (complications)
  • Pregnancy
  • Pregnancy Complications (physiopathology)
  • Rabbits

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