Experimental teratological studies with the mouse CNS mutations cranioschisis and delayed splotch.

Abstract

Teratological experiments were made with a recessive mouse gene (cranioschisis) causing exencephaly and a semidominant gene (delayed splotch) causing spina bifida. In studies with the cranioschisis gene administration of warfarin and thyroxine resulted in frequencies of exencephaly significantly below that expected of a recessive trait, perhaps indicating selective elimination of abnormal conceptuses. Studies with the delayed splotch gene tested the hypothesis that offspring with a hereditary defect of neural-tube closure have other, unexpressed CNS defects, which may be elicited by teratological impulses. This proposition was decisively upheld by administering 5-bromo-2'-deoxyuridine, cadmium sulfate and retinoic acid, as these treatments all caused significantly greater frequencies of induced exencephaly in offspring with spina bifida than in their genetically normal littermates.

• Authors: H Kalter
• Journal: Journal of craniofacial genetics and developmental biology. Supplement (J Craniofac Genet Dev Biol Suppl) Vol. 1 Pg. 339-42 ( 1985) ISSN: 0890-6661 [Print] United States
• PMID: 3902948 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Cadmium Compounds
• Sulfates
• Teratogens
• Cadmium
• Tretinoin
• Warfarin
• cadmium sulfate
• Bromodeoxyuridine
• Thyroxine

Topics

• Animals
• Bromodeoxyuridine (toxicity)
• Cadmium (toxicity)
• Cadmium Compounds
• Female
• Genes, Dominant (drug effects)
• Genes, Recessive (drug effects)
• Mice
• Mutation
• Pregnancy
• Skull (abnormalities, drug effects)
• Spina Bifida Occulta (chemically induced, genetics)
• Sulfates
• Teratogens (toxicity)
• Thyroxine (toxicity)
• Tretinoin (toxicity)
• Warfarin (toxicity)