Efficacy of Listerine antiseptic in inhibiting the development of plaque and gingivitis.

A 9-month double-blind controlled clinical study was conducted on adult subjects using either Listerine antiseptic, its vehicle control, or a water control in order to determine the efficacy of the antiseptic mouthrinse in inhibiting the development of plaque and gingivitis. Following screening examinations for minimal entry levels of plaque and gingivitis, all subjects received a complete prophylaxis. Subjects then continued their usual oral hygiene habits for a 3-week normalization period and were examined for soft tissue abnormalities and baseline measurements of plaque, gingivitis, and tooth stain. 2 additional prophylaxes were then performed, followed by a second baseline gingival examination. Zero plaque was re-established by rubber cup polishing and twice daily rinsing was begun. Soft tissue, plaque, gingivitis, and extrinsic tooth stain were evaluated after 1, 3, 6 and 9 months of rinsing with the randomly assigned mouthrinses. Results demonstrated that Listerine antiseptic significantly reduced the development of plaque at 1, 3, 6 and 9 months and the development of gingivitis at 9 months, as compared to its vehicle control or water control.
AuthorsJ M Gordon, I B Lamster, M C Seiger
JournalJournal of clinical periodontology (J Clin Periodontol) Vol. 12 Issue 8 Pg. 697-704 (Sep 1985) ISSN: 0303-6979 [Print] DENMARK
PMID3902908 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Infective Agents, Local
  • Mouthwashes
  • Adolescent
  • Adult
  • Anti-Infective Agents, Local (therapeutic use)
  • Clinical Trials as Topic
  • Dental Plaque (prevention & control, therapy)
  • Dental Plaque Index
  • Dental Prophylaxis
  • Double-Blind Method
  • Follow-Up Studies
  • Gingivitis (prevention & control, therapy)
  • Humans
  • Middle Aged
  • Mouthwashes (therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: