Double-blind crossover study of fenquizone compared to chlorthalidone in essential hypertension.

Abstract

The clinical efficacy and tolerability of fenquizone (10 mg), a thiazide-like diuretic, were studied in comparison with chlorthalidone (25 mg) in 20 hypertensive out-patients during a four-month treatment course. Both drugs were very active in reducing hypertension. Fenquizone proved to be more active on systolic blood pressure, while there were no differences between groups regarding diastolic blood pressure. Chlorthalidone induced a more significant loss of plasma K+ than fenquizone. Fenquizone showed also a significant decrease of symptoms (headache, dizziness) due to hypertension. No undesirable side effects were observed.

• Authors: P F Angelino, A Alvino-Demartino, R Mappa, C Donati
• Journal: International journal of clinical pharmacology, therapy, and toxicology (Int J Clin Pharmacol Ther Toxicol) Vol. 23 Issue 9 Pg. 501-5 (Sep 1985) ISSN: 0174-4879 [Print] Germany
• PMID: 3902676 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)

Chemical References

• Diuretics
• Quinazolines
• fenquizone
• Chlorthalidone
• Potassium

Topics

• Adult
• Aged
• Blood Pressure (drug effects)
• Chlorthalidone (therapeutic use)
• Clinical Trials as Topic
• Diuretics (therapeutic use)
• Double-Blind Method
• Drug Tolerance
• Female
• Humans
• Hypertension (drug therapy)
• Male
• Middle Aged
• Potassium (blood)
• Quinazolines (therapeutic use)
• Random Allocation
• Time Factors