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Protection against Yersinia infection induced by non-virulence-plasmid-encoded antigens.

Abstract
Specific immunity against Yersinia was induced by plasmid-encoded antigens not associated with virulence. Mice were immunised with viable bacteria from a virulence-plasmid-cured strain of Y. pseudotuberculosis. This antigenic stimulation generated specific protection against virulence-plasmid-harbouring strains of Y. pseudotuberculosis and Y. pestis, demonstrating that protection can be generated by organisms lacking plasmid-encoded virulence antigens.
AuthorsM Simonet, P Berche, D Mazigh, M Veron
JournalJournal of medical microbiology (J Med Microbiol) Vol. 20 Issue 2 Pg. 225-31 (Oct 1985) ISSN: 0022-2615 [Print] England
PMID3900406 (Publication Type: Journal Article)
Chemical References
  • Antigens, Bacterial
Topics
  • Animals
  • Antigens, Bacterial (genetics, immunology)
  • Female
  • Immunity, Active
  • Immunization
  • Listeriosis (immunology, microbiology)
  • Mice
  • Mice, Inbred ICR
  • Plague (immunology, microbiology)
  • Plasmids
  • Spleen (microbiology)
  • Virulence
  • Yersinia (genetics, growth & development, immunology, pathogenicity)
  • Yersinia Infections (immunology, microbiology)
  • Yersinia enterocolitica (growth & development, immunology)
  • Yersinia pestis (growth & development, immunology)
  • Yersinia pseudotuberculosis Infections (immunology, microbiology)

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